Publications
Recent work
Hoces*, D., Ng*, J., Perez*, J., Hernández-López, R.A., Rational Control of Basal CAR Expression Improves Discrimination in Inducible T Cell Circuits. Submitted (2026). [bioRxiv]
Cai*, B., Xue*, A., Xue, Q., Liu, N., Qiu, X., Hernández-López, R.A.#, and Ting, A.Y.#. Subcellular transcriptome sequencing with single cell APEX-seq identifies regulators of cell-cell interactions. Submitted (2026). [bioRxiv]
Obenaus, M., Poupault, C. L., McGinnis, C. S., Prange, C., Jiang, H., Su, L. L., Chen, X., Miao, Z., Muldoon, J. J., Yao, W., Waghray, D., Sun, Q., Eyquem, J., Hernández-López, R. A., Satpathy, A. T., Sage, J., Garcia, K. C. T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T cells. Submitted (2026). bioRxiv
Hernández-López, R.A.#, Kesti, T., Mäkelä, A.R., Zhao, Z., Yu, W., Tonai, Y., Monzo, H.J., Kalander, K., Leppä, S., Ojala, P. M., Lim, W. A.#,Saksela, K.# "Engineered SH3-Derived Sherpabodies Function as a Modular Platform for Targeted T Cell Immunotherapy". Cancer Research (2025), link.
S.-Y. Lee*, H. Roh*, D. Gonzalez-Perez, M. R. Mackey, D. Hoces, C. N. McLaughlin, C. Lin, S. R. Adams, K. Nguyen, K.-Y Kim, D. J. Luginbuhl, L. Luo, N. D. Udeshi, S. A. Carr, R. A. Hernández-López, M. H. Ellisman, M. Alcalde, and A. Y. Ting. "Directed evolution of LaccID for cell surface proximity labeling and EM". Nature Chemical Biology (2025), link.
Du, H., Mallik, L., Hwang, D., Sun, Y., Kaku, C., Hoces, D., ..., Hernandez-Lopez, R.A., Jardine, J.G., Sgourakis, N.G., Huang, P., Targeting peptide antigens using a multiallelic MHC I-binding system. Nat Biotechnology (2024). - link
Hoces, D., Miguens Blanco, J. Hernandez-Lopez, R.A., A synthetic biology approach to engineering circuits in immune cells, Immunological Reviews (2023) - link
Hernandez-Lopez,R.A., Yu, W., Cabral, K.A.*, Creasey, O.A.*, Lopez Pazmino, M.P., Tonai,Y., De Guzman, A., Mäkelä, A., Saksela, K., Gartner, Z.J., Lim, W.A “T cell circuits that sense antigen density with an ultrasensitive threshold”.
Science (2021). - link
Signal Transduction and Targeted Therapy
Annals of the New York Academy of Sciences
Cellular and Molecular Life Sciences
Huang, X., Williams, J.Z., Chang, R, Li, Z., Burnett, C.E., Hernandez-Lopez, R., Setiady, I., Gai, E., Patterson, D.M., Yu, W., Roybal, K.T., Lim, W.A.#, Desai, T.A.# “DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation”. Nature Nanotechnology (2020).
* Equal contribution
# Co-corresponding author
Ludington, W.B., Ishikawa, H., Serebrenik, Y.V., Ritter, A.*, Hernandez-Lopez, R.*, Gunzenhauser,J.*, Kannegaard, E., and Marshall, W.F. “A systematic comparison of mathematical models for inherent measurement of ciliary length: how a cell can measure length and volume”. Biophysical Journal (2015).
Ramirez-Cordero, B. , Toledano, Y., Cano-Sanchez, P., Hernandez-Lopez, R., Flores-Solis, D., Saucedo-Yanez, A, Chavez-Uribe, I., Brieba de Castro, L., and del Río-Portilla, F. “Cytotoxicity of recombinant tamapin and related toxin-like peptides on model cell lines”. Chemical research in toxicology (2014).
Gurrola Briones, G., Hernandez-Lopez, R., Rodriguez de la Vega, R., Varga, Z., Ferreira Batista, C., Salas-Castillo, S., Panyi, G., Del Rio-Portilla, F., and Possani, L. D. “Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes”. Biochemistry (2012).
RedwineW. B. *, Hernandez-Lopez, R.*, Zou, S., Huang, J., Reck-Peterson, S. L., and Leschziner, A. E. “Structural basis for microtubule binding and release by dynein”. Science (2012).
Saucedo-Yanez, A., Flores-Solis, D., Rodriguez de la Vega, R., Ramirez-Cordero, B., Hernandez-Lopez, R., Cano-Sanchez, P., Noriega-Navarro, R., Garcia-Valdez, J., Coronas-Valderrama, F., de Roodt, A., Brieba de Castro, L., Possani, L. D., and del Río-Portilla, F. “New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing”. The Journal of Biological Chemistry (2012).
Chandramouli P., Hernandez-Lopez, R., Wang, H., and Leschziner, A. “Validation of the orthogonalt tilt reconstruction method with a biological test sample”. Journal of Structural Biology (2011).
* Equal contribution